Antineoplasico anticuerpo monoclonal categorias farmacologicas farmacocinetica. Trastuzumab works by binding to the her2 receptor and slowing down cell duplication. Adotrastuzumab emtansine targets hepatocytes via human. Although there are currently other antiher2 agents available e. Trastuzumab 440 mg20 ml en ampula oncologia info medicamento. Nov 08, 2019 provides accurate and independent information on more than 24,000 prescription drugs, overthecounter medicines and natural products. Ado trastuzumab emtansine tdm1 is an antibodydrug conjugate adc approved for the treatment of her2positive metastatic breast cancer.
Iii study combining pertuzumab with trastuzumab and docetaxel in metastatic breast. Trastuzumab mechanism of action and use in clinical practice. Trastuzumab mechanism of action and use in clinical practice to the editor. It consists of trastuzumab, a humanized mab directed against her2, and a microtubule inhibitor, dm1, conjugated to trastuzumab. Pdf dual her2 targeting with trastuzumab and liposomal. Pdf molecular mechanisms of trastuzumab resistance in her2. It is on the world health organizations list of essential medicines, the safest and most effective medicines needed in a health system. Trastuzumab is a humanized monoclonal antibody that targets her2. Herceptin indicaciones, dosificacion, presentacion, efectos.
This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Uncertainty over theoptimal duration of adjuvant trastuzumab therapy 5 july 20071extends to optimal sequencingandlongterm outcomes. In patients with her2positive metastatic breast cancer, pertuzumab added to trastuzumab and docetaxel has been shown to significantly prolong both progressionfree survival and overall survival. Trastuzumab was approved for medical use in the united states in 1998. Dual her2 targeting with trastuzumab and liposomalencapsulated doxorubicin mm 302 demonstrates synergistic antitumor activity in breast and gastric cancer.